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Isolierung von Streptothricin‐resistenten Mutanten aus Escherichia coli K12, Stamm A19
Author(s) -
Seidel L.,
Haupt Ina
Publication year - 1982
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19820220209
Subject(s) - escherichia coli , chemistry , aminoglycoside , mutant , antibiotics , microbiology and biotechnology , biology , biochemistry , gene
Mutants with various levels of resistance to streptothricin were isolated from Escherichia coli K12, strain A19 after mutagenesis with N‐methyl‐N'‐nitroso‐guanidine and ethylmethane‐sulfonate. Nourseothricin, a mixture of streptothricin F. and D was the selection agent. Spontaneous resistant mutants could not be found. The streptothricin‐resistant mutant E. coli A19 Stcr 2/2/1 shows cross‐resistance to some of the aminoglycoside antibiotics investigated, but no cross‐resistance to chloramphenicol and chlortetracyclin. These results indicate similar mechanisms of action of streptothricin and aminoglycoside antibiotics.