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Convergence between global BCG vaccination and COVID‐19 pandemic
Author(s) -
Islam Md. Zahurul,
Zahan Md. KudratE,
AlBari Md. Abdul Alim
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26450
Subject(s) - pandemic , vaccination , virology , context (archaeology) , herd immunity , coronavirus , medicine , transmission (telecommunications) , coronaviridae , immunology , covid-19 , infectious disease (medical specialty) , biology , disease , computer science , paleontology , pathology , telecommunications
Abstract The novel coronavirus severe acute respiratory syndrome coronavirus 2 ( SARS‐CoV‐2 ) has kept the whole world in tenterhooks due to its severe life‐threatening infectious disease, COVID‐19. The virus is distinct from its cousins, SARS‐CoV and MERS‐CoV in terms of severity of the infection. The obligated killing properties of the SARS‐CoV‐2 virus is mediated by its unique structure. Efforts for developing vaccines for COVID‐19 are ongoing, but it is unlikely to be available in the immediate future. Due to the absence of precise treatment, the investigators are discovering other effective, protective, and healing choices. However, the lower than a predictable number of SARS‐CoV‐2 cases in countries with fragile health systems is mystifying. Recently, there has been a buzz about the protective effect of Bacille Calmette‐Guérin ( BCG ) vaccine in COVID‐19 through long‐term boosting of trained immunity. Based on epidemiological correlations , we link up that BCG vaccination adopted by different countries might influence the SARS‐CoV‐2 transmission patterns and/or COVID‐19 associated mortality through the vaccine's capacity to confer heterologous protection. A number of clinical studies are underway to investigate this possibility but even if they prove effective‐many questions will remain. Moreover, responsible stewardship of the BCG vaccine in the context of the COVID‐19 epidemic is directly needed.