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Molecular characterization and clinical epidemiology of human respiratory syncytial virus (HRSV) A and B in hospitalized children, Southern Brazil
Author(s) -
Moreira Francielli B.,
Rosario Cristine S.,
Santos Jucelia S.,
Avanzi Valéria M.,
Nogueira Meri Bordig,
Vidal Luine R.,
Raboni Sonia Mara
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24795
Subject(s) - interquartile range , genotype , virus , virology , mononegavirales , epidemiology , respiratory system , pneumovirinae , paramyxoviridae , biology , respiratory disease , disease , molecular epidemiology , genetic variability , immune system , viral disease , medicine , immunology , genetics , gene , lung
Human respiratory syncytial virus (HRSV) is a major etiologic agent of pediatric respiratory infections. Genetic variability of its glycoprotein G enables HRSV to evade the immune response and determines its seasonal dissemination. This study reports genetic variability and clinical profiles of HRSV‐infected patients from Southern Brazil. Seventy positive samples, 78% type A and 22% type B, were analyzed. Of the patients (median age, 6 months; interquartile range, 2‐11 years), 16% had co‐morbidities and 17% developed severe disease. The ON1 HRSV genotype first appeared in 2012, and patients infected with this genotype showed an increased tendency to develop severe disease.