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Potential for combined therapy with 348u87, a ribonucleotide reductase inhibitor, and acyclovir as treatment for acyclovir‐resistant herpes simplex virus infection
Author(s) -
Safrin S.,
Schacker T.,
Delehanty J.,
Hill E.,
Corey L.
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890410528
Subject(s) - ribonucleotide reductase , thymidine kinase , herpes simplex virus , virology , aciclovir , virus , biology , nucleoside analogue , herpesviridae , medicine , viral disease , nucleoside , protein subunit , biochemistry , gene
Abstract Inhibitors of the ribonucleotide reductase of herpes simplex viruses (HSV) potentiate the activity of acyclovir in vitro and in animal studies. In addition, the combination of the ribonucleotide reductase inhibitor 348U87 and acyclovir has synergistic therapeutic effects against infections in mice due to thymidine kinase‐deficient, thymidine kinase‐altered, and DNA polymerase mutants of HSV. We performed a pilot study of topical combination therapy with 348U87 (3%) and acyclovir (5%) cream for acyclovir‐resistant, anogenital HSV infections in ten human immunodeficiency virus (HIV)‐infected patients. Our results, with lack of complete reepitheliazation of lesions in all patients and poor virologic response, suggest that this therapy is unlikely to be useful for this indication.