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Mass spectrometric studies of trimethylsilylpantothenic acid and related substances
Author(s) -
Rychlik Michael
Publication year - 2001
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.157
Subject(s) - chemistry , fragmentation (computing) , electron ionization , collision induced dissociation , mass spectrometry , dissociation (chemistry) , labelling , polyatomic ion , analytical chemistry (journal) , ion , ionization , radiochemistry , chromatography , tandem mass spectrometry , organic chemistry , biochemistry , computer science , operating system
Abstract The characteristic fragment of trimethylsilylated pantothenic acid (TMS‐PA) at m / z 291 upon electron ionization was shown to originate from the molecular ion by a McLafferty rearrangement instead of by ejection of 1,1,3,3‐tetramethyl‐1,3‐disilacyclobutane. The verification consisted of labelling experiments and high‐resolution mass spectrometry of the fragment and studies on its isotopic distribution. The remaining fragmentation pathways of TMS‐PA were clarified by B / E ‐linked scans and collision‐induced dissociation. Copyright © 2001 John Wiley & Sons, Ltd.