The synthesis of the α v β 3  integrin receptor ligand [ 125 I]L‐775,219 | Zendy

Hamill Terence G. | Zendy; Duggan Mark E. | Zendy; Perkins Jim J. | Zendy

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The synthesis of the α v β 3 integrin receptor ligand [ 125 I]L‐775,219

Author(s) -

Hamill Terence G.,

Duggan Mark E.,

Perkins Jim J.

Publication year - 2001

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.432

Subject(s) - chemistry , ligand (biochemistry) , iodide , yield (engineering) , receptor , integrin , stereochemistry , in vitro , medicinal chemistry , biochemistry , organic chemistry , physics , thermodynamics

The α v β 3 integrin receptor ligand [ 125 I]L‐775,219, 1c , was synthesized for use in an in vitro receptor binding assay with high specific activity (>1500 Ci/mmol) and a radiochemical yield of 15–20%. Conversion of iodide 1b to the corresponding aryl trimethylstannane 2 , followed by radioiodination using Na 125 I/iodobead gave 1c . Copyright © 2001 John Wiley & Sons, Ltd.

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