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Positron emission tomography radioligands for the opioid system
Author(s) -
Dannals Robert F.
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3005
Subject(s) - miosis , chemistry , positron emission tomography , dysphoria , euphoriant , opiate , neuroscience , radioligand , spinal cord , psychology , μ opioid receptor , opioid , pharmacology , receptor , anxiety , psychiatry , medicine , biochemistry
Opiate receptors are found in the brain, the spinal cord, some peripheral sensory neurons, and the gastrointestinal tract. Naturally occurring and synthetic opiate ligands exert their influence on a wide variety of processes including analgesia, euphoria, dysphoria, sedation, respiratory depression, and miosis and are frequently topics for discussions on addiction and physical dependence. This review looks at the history of positron emission tomography radioligands for probing this receptor system.