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Synthesis of 1‐4′ ‐ethylphenoxy‐ 14 C (U) ‐6,7 ‐epoxy‐ 3,7 ‐dimethyl‐2 ‐octene. A juvenile hormone analog
Author(s) -
Kalbfeld J.,
Hoffman L. J.,
Chan J. H.,
Hermann D. A.
Publication year - 1973
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590090403
Subject(s) - epoxy , chemistry , juvenile hormone , potassium carbonate , acetone , nuclear chemistry , hormone , chromatography , organic chemistry , biochemistry
The preparation of 1‐4′ ethylphenoxy‐ 14 C(U)‐6, 7‐ epoxy ‐ 3, 7‐dimthyl‐2‐octene ( 1 , 2 ) involved a single reaction wherein 4‐ethlphenol‐ 14 C(U) ( 3 ) was mixed with 1‐chloro‐6, 7‐epoxy‐3, 7‐dimithyl‐2‐octene in an acetone water solution at reflux lu‐sing potassium carbonate as a hydrogen chloride acceptor. Althoug this juvenile hormone analog (JHA) normally shows good shelf stabilety, the quality of the labeled material which had been purified by Colum Chromatography deterio‐rated significantly when stored neat for a period of 17 days.