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The synthesis of 14 C‐labelled 1‐(4‐chlorophenyl) ‐2‐methyl‐2‐amino‐propane hydrochloride (chlorphentermine, Desopimon®)
Author(s) -
Engler J.,
Pallos L.
Publication year - 1973
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590090110
Subject(s) - hydrochloride , chemistry , yield (engineering) , propane , thin layer chromatography , organic chemistry , materials science , metallurgy
The preparation of 14 C labelled 1‐(4‐chlorophenyl)‐2‐methy 1‐2‐aminopropane hydrochloride is described. The radioactive carbon was introduced into the central position of the aminopropyl group in order to study the pharmacological properties and mode of action of the anorexigenic drug. The synthesis started from Ba 14 CO 3 , involved 3 steps, and a radiochemical yield of 23% was obtained. The chemical and radiochemical purity of the end‐product was proved by thin layer chromatography and autoradiography.