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Synthesis of organic compounds labelled with hydrogen isotopes. I ‐ exchange of halogen atoms in halohydrins for hydrogen isotopes to prepare alcohols labelled with deuterium or tritium
Author(s) -
Egyed J.,
Neszmélyi A.,
Beke I.,
Baitz E.
Publication year - 1972
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590080409
Subject(s) - halogen , chemistry , hydrogen , tritium , deuterium , radiochemistry , substituent , reagent , inorganic chemistry , isotope , organic chemistry , alkyl , physics , quantum mechanics , nuclear physics
A method has been developed for the preparation of alcohols labelled with hydrogen isotopes, from halohydrins. The synthesis has been performed via Grignard reagents in one step, in the course of which the halogen substituent has exchanged for magnesium which then exchanges for the hydrogen isotope required