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Preparation of tritium‐labeled compounds. IV. A group of steroids by exposure to tritium gas
Author(s) -
Thomas Richard C.,
Ikeda George J.,
Reineke Lester M.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070418
Subject(s) - tritium , tritium illumination , chemistry , radiochemistry , catalysis , platinum , methylprednisolone , nuclear chemistry , organic chemistry , medicine , nuclear physics , physics
Abstract Hydrocortisone, 21‐desoxy‐9α‐fluoro‐6α‐methylprednisolone, and 6α‐methylprednisolone, 21‐acetate were labeled with tritium by the Wilzbach tritium‐gas exposure method. The latter compound was also tritiated by exposure to tritium gas in the presence of a platinum‐black catalyst. Although extensive purifications were required, in each case radiochemically pure material of sufficiently high specific activity for its intended use was obtained. Incorporation of stably bound tritium was nine times greater by catalytic tritiation than by the conventional Wilzbach method.