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Mise en évidence de groupements actifs dans les alkylpyrimidines. Étude de la mobilité des Hydrogènes par échange isotopique hydrogène‐deutérium. I. ‐ Étude cinétique qualitative
Author(s) -
Dizabo Pierre,
Monier JeanClaude,
Pompon Alain
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070403
Subject(s) - hydrogen–deuterium exchange , chemistry , medicinal chemistry , alkyl , deuterium , hydrogen , organic chemistry , physics , quantum mechanics
Methyl groups bound to heterocyclic rings may, in certain circumstances, exchange hydrogen for deuterium. This exchange has been studied for alkyl or amino‐alkylpyrimidines in acid medium. The qualitative results obtained as a function of acidity, substituant location and temperature confirm the reaction mechanism proposed by Brown except in the case of amino‐2 dimethyl‐4, 6 pyrimidine.