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Synthesis of 6‐n‐propyl‐2‐thiouracil‐6− 14 C
Author(s) -
Thornhill D. P.,
Sitar D. S.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070207
Subject(s) - sodium ethoxide , chemistry , thiourea , yield (engineering) , thiouracil , sodium , butyric acid , butyrate , nuclear chemistry , medicinal chemistry , saccharin , organic chemistry , chloride , ethanol , materials science , medicine , thyroid , fermentation , metallurgy
6‐n‐Propyl‐2‐thiouracil‐6− 14 C was prepared from sodium butyrate‐1− 14 C, with a radiochemical yield of 34%. Butyryl chloride‐1− 14 C was prepared from butyric acid‐1− 14 C and condensed with sodio ethylacetoacetate to yield ethyl β‐oxohexanoate‐β− 14 C. The β‐keto ester was condensed with thiourea in sodium ethoxide to yield the 2 substituted thiouracil.