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Synthesis and identification of 2‐dimethylamino‐5‐(phenyl‐2′‐ 3 H)‐2‐oxazolin‐4‐one
Author(s) -
Howell Charles F.,
Van Lear George,
Hardy Robert A.
Publication year - 1970
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590060411
Subject(s) - tritium , derivative (finance) , ring (chemistry) , chemistry , mass spectrum , medicinal chemistry , isotope , mass spectrometry , organic chemistry , physics , nuclear physics , chromatography , financial economics , economics
The title compound 1b was prepared by tritiolysis of 5‐(O‐bromophenyl)‐2‐dimethylamino‐2‐oxazolin‐4‐one, 2 , with 10 Ci of tritium and diluted with unlabelled 1a . The mass spectrum of the 2′ ‐deutero derivative 1c , prepared similarly, showed that 92.9 % of labelled compound was D l with only 3.1 % D 2 and that > 95 % of the isotope was in the aromatic ring.