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Synthesis of cholesterol‐20‐ 14 C
Author(s) -
Porto Ana M.,
Gros Eduardo G.
Publication year - 1970
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590060410
Subject(s) - cholesterol , chemistry , pregnenolone , diol , diene , organic chemistry , medicinal chemistry , nuclear chemistry , biochemistry , steroid , natural rubber , hormone
Cholesterol‐20‐ 14 C was synthesized in four steps from pregnenolone‐20‐ 14 C. The labelled intermediates were proven to be cholest‐5‐ene‐3β, 20α‐diol acetate‐3, cholesta‐5, 20 (22)‐diene‐3β‐ol acetate, and cholesterol acetate by 1 H‐n.m.r. spectroscopical analysis. Cholesterol‐20‐ 14 C was obtained with a radiochemical purity exceeding 99%.