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Ethyl chlorocarbonate‐ 14 C and its application to the synthesis of N‐methyl‐ 14 C‐amines
Author(s) -
Marshall F. J.,
McMahon R. E.
Publication year - 1970
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590060306
Subject(s) - aluminum hydride , lithium (medication) , hydride , chemistry , carbamate , medicinal chemistry , lithium hydride , aluminium , nuclear chemistry , inorganic chemistry , organic chemistry , ion , hydrogen , ionic bonding , medicine , endocrinology , methoxide
A convenient method for the preparation of ethyl chlorocarbonate‐ 14 C is described. This has led to a facile synthesis of N‐methyl‐ 14 C secondary amines by lithium aluminum hydride reduction of an intermediate 14 C‐carbamate. The reaction has also been employed in the preparation of N‐methyl‐ 2 H 3 ‐ and N‐methyl‐ 3 H‐amines by using lithium aluminum hydride‐ 2 H 4 and lithium aluminum hydride‐ 3 H.