Premium
The preparation and purification of labelled β‐adrenergic blocking agents. Part I. Synthesis of carbon‐14 and tritium labelled 1‐isopropylamino‐3‐(1‐naphthyloxy)‐propan‐2‐ol hydrochloride, (propranolol hydrochloride, inderal
Author(s) -
Burns J.
Publication year - 1970
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590060107
Subject(s) - propranolol , tritium , propranolol hydrochloride , chemistry , hydrochloride , acetic acid , specific activity , nuclear chemistry , radiochemistry , chromatography , catalysis , organic chemistry , enzyme , anesthesia , medicine , physics , nuclear physics
The preparation of 14 C‐propranolol hydrochloride from 1‐naphthol‐1‐ 14 C is described. Several preparations of the compound have been carried out with overall radiochemical yields of 17 %‐21 %. Specific activities of 3.51 μCi/mg, 8.8 μCi/mg, and 23.2 μCi/mg have been obtained. Propranolol has also been tritium labelled non specifically by catalytic exchange with tritiated acetic acid. After extensive purification pure material with a specific activity of 940 μCi/mg was obtained.