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Synthesis of the hepatocarcinogen N‐methyl‐4‐aminoazobenzene with tritium in the prime ring
Author(s) -
Lin JenKun,
Miller James A.
Publication year - 1969
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590050307
Subject(s) - aniline , ring (chemistry) , chemistry , yield (engineering) , acetic acid , tritium , prime (order theory) , hydrolysis , acetic anhydride , ethanol , medicinal chemistry , organic chemistry , mathematics , catalysis , materials science , physics , combinatorics , nuclear physics , metallurgy
Abstract The new compound N‐methyl‐4‐nitrosoacetanilide was coupled with aniline‐ 3 H (ring‐G) in ethanol‐acetic acid and the resulting azoamide was hydrolyzed in alkali to give a high yield of N‐methyl‐4‐aminoazobenzene labelled in the prime ring.