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Deuteration of a substrate to high isotopic purity with low grade heavy water
Author(s) -
Rosatzin H.
Publication year - 1968
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590040304
Subject(s) - deuterium , chemistry , heavy water , substrate (aquarium) , radiochemistry , nuclear physics , physics , oceanography , geology
Abstract Deuterium chemistry is still quite costly, mainly because of the high prices of deuterated compounds needed for syntheses. Furthermore, the risk of diluting isotopically the compounds prepared is considerable. These disadvantages can be alleviated, if i) the deuterium of the D‐donator is exchanged efficiently, ii) highly deuterated solvents and reactants can is be prepared conveniently on a laboratory scale, and iii) compounds, which have been isotopically diluted can be reconcentrated conveniently. Fulfillments of these requirements allows for research in deuterium chemistry on a close to pilot plant scale at tolerable costs. With this aim in mind, basic principles of batch deuterations on pilot plant scale with low grade heavy water discussed. By up‐grading D 2 O wastes, close to 98 % of the deuterium employed for reaction can be incorporated into the substrate.