Premium
Recoil labeling and selective radiation labeling a novel synthesis of propanol‐2,3‐ 14 C 1
Author(s) -
Oae Shigeru,
Redvanly Carol S.,
Wolf Alfred P.
Publication year - 1968
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590040106
Subject(s) - chemistry , methanol , propanol , isotopic labeling , ethylene , recoil , radiochemistry , irradiation , organic chemistry , catalysis , nuclear physics , physics
A recoil labeling method for the production of propanol‐2,3‐ 14 C 1 and other simple alcohols is described. In addition propanol‐2,3‐ 14 C and 2‐methyl propanol‐3‐ 14 C were prepared by the irradiation of methanol solutions of ethylene‐ 14 C and propene‐1‐ 14 C, respectively, in „scavenger” concentration. This latter approach called selectiveradiation labeling is explored as a method for the preparation of specifically labeled compounds by „non‐synthetic” methods. The advantages of selective radiation labeling are : 1. specificity of label; 2. ready control of desired specific activity; 3. efficient use of the labeling isotope in an appropriate precursor; 4. ease of purification and isolation of products; 5. minimum labor. Any source of penetrating radiation can be used in selective radiation labeling.