Premium
Synthesis of 14 C‐lanosterol and 14 C‐desmosterol
Author(s) -
Danieli B.,
Russo G.
Publication year - 1965
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590010404
Subject(s) - lanosterol , desmosterol , phosphorane , chemistry , wittig reaction , stereochemistry , biochemistry , cholesterol , sterol
The synthesis of lanosterol [ I a] and desmosterol [ IIa ] labeled with 14 C in the 25 position by a Wittig reaction between triphenyl‐2 14 C isopropylidene‐phosphorane [ IVb ] and the corresponding aldehydes are described. The specific activities obtained are, respectively, 0.539 mC/mM and 0.752 mC/mM and the purities of the compounds, respectively, 96 and 99%.