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Comparison of the predicted behaviour of 153 Sm, 166 Ho and 117m Sn containing bone agents, employing blood plasma models (ECCLES), with in vivo results as studied in animals
Author(s) -
Zeevaart J. R.,
Jarvis N. V.,
Louw W. K. A.,
Wagener J. M.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401281
Subject(s) - in vivo , chemistry , genetic algorithm , ligand (biochemistry) , radiochemistry , biochemistry , receptor , genetics , biology
Predictions regarding the in vivo behaviour of 153 Sm, 166 Ho and 117m Sn containing radiopharmaceuticals were made using speciation studies. The speciation of the metal ion and ligand of the radiopharmaceutical in blood plasma was calculated using the ECCLES computer code. Predictions were verified by clinical observations as studied in animals.