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Preraration of a new 99m Tc nitrido complex and its biodistribution in mice
Author(s) -
Zhang J. B.,
Wang X. B.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401196
Subject(s) - biodistribution , chemistry , dithiocarbamate , radiochemistry , sodium , nuclear chemistry , medicinal chemistry , organic chemistry , biochemistry , in vitro
The complex 99m TcN‐CBDTC(CBDTC: N‐cyclobutyl dithiocarbamato) was synthesized by the reduction of 99m TcO 4 − into [ 99m TcN] 2+ with stannous chloride in the presence of succinic dihydrazide and propylenediamine tetraacetic acid, followed by the addition of sodium N‐cyclobutyl dithiocarbamate trihydrate. Biodistribution in mice showed that the complex was significantly retained into the brain. The brain uptake(ID%/g) was 3.61, 3.15 and 2.62 and the brain/blood ratio was 1.00, 1.44 and 1.30 at 5, 30 and 60min post‐injection, respectively. The results for the complex suggested that it could be a potential brain‐perfusion imaging agent.