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Characterisation of co‐polymer targeting of doxorubicin and its iodinated conjugate in tumour models
Author(s) -
Klinski E.,
Li S.,
Zweit J.,
Hadfield J.,
Bailey J.,
Alakhov V.,
Ranson M.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401140
Subject(s) - conjugate , doxorubicin , chemistry , in vivo , pharmacokinetics , conjugated system , synthetic polymer , polymer , drug delivery , drug , pharmacology , combinatorial chemistry , chemotherapy , organic chemistry , medicine , mathematical analysis , mathematics , microbiology and biotechnology , biology
This study was undertaken towards enabling PET imaging of polymer‐based drug delivery. Iodinated doxorubicin conjugate (DOXIB) was characterised against un‐conjugated DOX within and outside a polymer formulation in tumour cell lines and tumour bearing animal models. The results provide the basis for developing the feasibility of [ 124 I]‐DOXIB PET to assess in vivo pharmacokinetics of drug formulation.