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N. C. A. radioiodination of idoxifene
Author(s) -
Trivedi Mahendra,
Potter Gerrard,
Hammersley Peter,
Carnochan Paul,
Young Helen,
Jarman Michael,
Ott Robert
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580361003
Subject(s) - chemistry , tamoxifen , electrophile , high performance liquid chromatography , chromatography , organic chemistry , breast cancer , cancer , medicine , catalysis
We describe a method for n.c.a. radioiodination of pyrrolidino tamoxifen (Idoxifene) based on the electrophilic destannylation of tributylstannyl pyrrolidino tamoxifen. The methods of separation using preparative tlc and HPLC give >95% radiochemical purity and >70% recovery.