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Synthesis of mixed halogenated trihalomethanes labelled with the stable isotopes 2 H or 13 C
Author(s) -
Vermeulen H. L.,
Sangaiah R.,
Ball L. M.,
Gold A.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360904
Subject(s) - chemistry , chloroform , nuclear magnetic resonance spectroscopy , gas chromatography , chloride , isotopes of chlorine , mass spectrometry , radiochemistry , carbon 13 , nuclear chemistry , isotope , organic chemistry , chlorine , chromatography , physics , quantum mechanics
2 H and 13 C‐labelled bromodichloromethane and chlorodibromomethane were obtained in yields of 20 and 12% (for 2 H) and 6 and 3% (for 13 C) respectively from a convenient aluminum chloride‐catalyzed reaction of bromoethane with commercially‐available isotopically‐substituted chloroform. The products were purified by preparative gas chromatography and characterized by MS and 13 C NMR, and by 1 H for the 13 C‐labelled material; mass and nuclear magnetic resonance spectroscopy data are reported.