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Deuteration of acetanilides and other substituted aromatics using [Ir(COD)(Cy 3 P)(Py)]PF 6 as catalyst
Author(s) -
Hesk D.,
Das P. R.,
Evans B.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360514
Subject(s) - chemistry , acetanilide , catalysis , acetophenone , deuterium , labelling , benzophenone , hydrogen–deuterium exchange , medicinal chemistry , organic chemistry , hydrogen , biochemistry , physics , quantum mechanics
Deuterium exchange labelling using [Ir(COD)(Cy 3 P)(Py)]PF 6 as catalyst and deuterium gas was studied on a number of substituted acetanilides. In most cases products containing deuterium ortho to the anilide group were obtained with a high degree of enrichment. With one exception no evidence for meta , para or anilide methyl labelling was seen. The catalyst was also effective in the ortho deuteration of acetophenone, benzophenone and the β‐lactam containing compound Sch 48461.