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Synthesis of tritium labelled 2‐vinyl dihydrosphingosine‐1‐phosphate
Author(s) -
Boumendjel Ahcene,
Miller Stephen P. F.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360411
Subject(s) - chemistry , sphingosine 1 phosphate , tritium , phosphate , sphingosine , covalent bond , organic chemistry , biochemistry , physics , receptor , nuclear physics
The synthesis of [1,1,3‐ 3 H]‐2‐vinyl dihydrosphingosine‐1‐phosphate is described. The key step in this synthesis is the reduction of methyl 2‐trifluoro acetamido‐2‐vinyl nonadecanoate‐3‐one by means of 3 H‐calcium diborohydride. This compound was synthesized to determine whether 2‐vinyl dihydrosphingosine‐1‐phosphate inhibits the PLP‐dependent sphingosine‐1‐phosphate lyase irreversibly via covalent modification.