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Synthesis of 3,5,6‐trichloropyridin‐2‐ol‐2,3,4,5,6‐ 13 C 5 ‐N; a metabolite of O,O‐diethyl‐O‐(3,5,6‐trichloro‐2‐pyridyl)‐phosphorothioate (chlorpyrifos)
Author(s) -
Nomura Glenn S.,
Patterson Donald G.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360406
Subject(s) - chemistry , acrylonitrile , metabolite , chloride , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , copolymer , polymer
A stable isotope‐labelled analog of 3,5,6‐trichloropyridin‐2‐ol has been synthesized. 3,5,6‐Trichloropyridin‐2‐ol‐2,3,4,5,6‐ 13 C 5 ‐ 15 N was synthesized in a copper catalyzed cyclization from trichloroacetyl chloride‐1,2‐ 13 C 2 and acrylonitrile‐1,2,3‐ 13 C 3 ‐ 15 N.