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Synthesis of N‐[4‐[2‐(2,4‐dimethylphenoxy)phenyl]‐2‐thiazolyl]‐hexahydro‐2‐pyrimidinimine, [ 14 C]BAY w 6341
Author(s) -
Pleiss Ulrich,
Conrad Michael,
Baasner Bernd
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360310
Subject(s) - chemistry , yield (engineering) , bay , malonate , diethyl malonate , sequence (biology) , medicinal chemistry , radiochemistry , stereochemistry , organic chemistry , catalysis , biochemistry , civil engineering , materials science , engineering , metallurgy
The title compound [ 14 C]BAY w 6341 was synthesized as part of a 4‐step sequence. Starting from diethyl [2‐ 14 C]malonate the final product ( 8 ) was obtained with a specific activity of 1.2 GBq/mmol (32.9 mCi/mmol) and a radiochemical purity of > 99 % in an overall yield of 19 %.