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Synthesis of high specific activity 17α‐cyanomethyl‐17β‐hydroxy‐[14α,15α‐ 3 H]estra‐4,9‐dien‐3‐one
Author(s) -
Droescher P.,
Röomer J.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360203
Subject(s) - chemistry , dienogest , tritium , specific activity , radiochemistry , chemical synthesis , medicinal chemistry , organic chemistry , in vitro , enzyme , biochemistry , nuclear physics , medicine , endometriosis , physics
An improved synthesis of the tritium labelled form of the new pharmacon DIENOGEST is described. The [ 14 α,15α‐ 3 ‐H]DIENOGEST was obtained with a specific activity of 51 Ci/mmol and a radiochemical purity > 98%.