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A single‐mode microwave cavity for reducing radiolabelling reaction times, demonstrated by alkylations with [ 11 C]alkyl halides
Author(s) -
StoneElander Sharon A.,
Elander Nils,
Thorell JanOlov,
Solås Gunnar,
Svennebrink Jan
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580341008
Subject(s) - chemistry , halide , microwave , isopropyl , alkyl , iodide , methyl iodide , radiochemistry , organic chemistry , quantum mechanics , physics
A single‐mode microwave cavity was constructed for microscale reactions with consideration taken to the space limitations typical for shielded working spaces used with positron emitting radionuclides. The effect of the microwave field in this cavity on typical reaction media is demonstrated. Reaction times for radiolabelling neuroreceptor ligands with [ 11 C]methyl iodide and [2‐ 11 C]isopropyl iodide were shown to be considerably reduced compared with the times reported in the literature for the corresponding thermal procedures.