Premium
Preparation of deuteriated benzylamines and phenethylamine with raney alloys in an alkaline deuterium oxide solution
Author(s) -
Tsukinoki Takehito,
Tsuzuki Hirohisa,
Ishimoto Keiko,
Nakayama Kouji,
Kakinami Takaaki,
Mataka Shuntaro,
Tashiro Masashi
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340906
Subject(s) - chemistry , amine gas treating , benzonitrile , amine oxide , phenethylamine , medicinal chemistry , oxide , deuterium , organic chemistry , stereochemistry , alkyl , physics , quantum mechanics
Benzyl‐α,α‐ 2 H 2 ‐amine, 2‐ 2 H 1 ‐Benzyl‐α,α‐ 2 H 2 ‐amine, 3‐ 2 H 1 ‐Benzyl‐α,α‐ 2 H 2 ‐amine, 4‐ 2 H 1 ‐Benzyl‐α,α‐ 2 H 2 ‐amine, 2, 5‐ 2 H 2 ‐Benzyl‐α,α‐ 2 H 2 ‐amine, and phenethyl‐α,α,β,β‐ 2 H 4 ‐amine were prepared in high isotopic purities from the corresponding benzonitrile, bromobenzonitriles, and phenylacetonitrile by reduction with Raney Cu‐Al alloy in an alkaline deuterium oxide solution.