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Synthesis of mutagenic 2,4‐dinitro‐[7‐ 14 C]benzaldehyde
Author(s) -
Shoji Miki,
Mori MasaAki,
Sayama Michio,
Kozuka Hiroshi,
Honda Takashi
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340703
Subject(s) - benzaldehyde , chemistry , toluene , yield (engineering) , adduct , macromolecule , radiochemistry , organic chemistry , nuclear chemistry , biochemistry , catalysis , materials science , metallurgy
2,4‐Dinitro‐[7‐ 14 C]benzaldehyde ( 4 ), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐ 14 C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.