Premium
Synthesis of sodium [ 11 C]thiocyanate using [ 11 C]cyanogen bromide
Author(s) -
Westerberg Göran,
Långström Bengt
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340608
Subject(s) - chemistry , cyanogen bromide , thiocyanate , sodium thiocyanate , bromide , sodium bromide , sodium , potassium thiocyanate , radiochemistry , nuclear chemistry , inorganic chemistry , organic chemistry , biochemistry , peptide sequence , gene
A method for the preparation of sodium ( 11 C]thiocyanate from [ 11 C]cyanogen bromide and sodium sulfide is described. Sodium [ 11 C]thiocyanate was obtained in 94% decay‐corrected radiochemical yield with a specific radioactivity of 122 GBq μmol −1 (3.3 Ci μmol −1 ) in a synthesis time of 21 minutes. The sodium [ 11 C]thiocyanate was used in the synthesis of ethyl‐, isopropyl‐, and benzyl [ 11 C]thiocyanate in 78, 71 and 84% radiochemical yields, respectively.