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Synthesis of isotopically labelled WIN 33377, an anticancer agent related to hycanthone
Author(s) -
Duffin Gordon R.,
Ellames George J.,
Smith David I.,
Wedge Karen J.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340509
Subject(s) - chemistry , cyanide , combinatorial chemistry , radiochemistry , stereochemistry , organic chemistry
14 C labelled and 13 C, 15 N labelled WIN 33377,1, 1‐(2‐diethylaminoethylamino)‐4‐(methanesulphonamidomethyl)thioxanthen‐9‐one, have been prepared by related routes using the known 1‐(2‐diethyl‐aminoethylamino)thioxanthen‐9‐one, 4 , as starting material and introducing the label with cyanide prior to further elaboration.