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Preparation of 14 C‐labelled dimethylsilane‐1,1‐diol
Author(s) -
Cella J. A.,
Carpenter J. C.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340504
Subject(s) - dimethylsilane , chemistry , radiochemistry , diol , organic chemistry
The preparation of 14 C‐labelled dimethylsilane‐1, 1‐diol in two steps from 14 C‐labelled diphenyldimethylsilane is described. Aluminum chloride catalyzed protodesilylation of diphenyldimethylsilane with HCl in dichloromethane or dimethyldichlorosilane at 0–5°C affords labelled dimethyldichlorosilane which is hydrolyzed in the presence of triethylamine to afford the title compound in 45–60% yield.