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The solid‐state synthesis of tritium labelled heterocyclic bases
Author(s) -
Sidorov Georgy V.,
Myasoedov Nikolai F.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340406
Subject(s) - chemistry , tritium , yield (engineering) , catalysis , palladium , intramolecular force , radiochemistry , pyrimidine , organic chemistry , stereochemistry , materials science , physics , nuclear physics , metallurgy
The results of a study of. the solid‐state catalytic hydrogenation and the synthesis of tritium labelled native heterocyclic bases are presented. The effect of different palladium catalysts and reaction conditions on yield and molar radioactivity of final compounds was investigated. For some compounds, data on the intramolecular distribution of tritium were obtained by using the isotope exchange reaction and tritium NMR. Tritium labelled purine and pyrimidine bases (25–180 Ci/mmol.) were synthesized.