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Synthesis of 14 C‐labelled aminoguanidine
Author(s) -
Lo Theodore W. C.,
Thornalley Paul J.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340211
Subject(s) - chemistry , cyanamide , yield (engineering) , hydrazine (antidepressant) , crystallization , salt (chemistry) , bicarbonate , chemical synthesis , barium , radiochemistry , nuclear chemistry , medicinal chemistry , organic chemistry , chromatography , in vitro , biochemistry , materials science , metallurgy
[ 14 C]Aminoguanidine was synthesized by the reaction of hydrazine sulphate with barium [ 14 C]cyanamide in a one‐step synthesis, and conveniently isolated by crystallization as the bicarbonate salt. The yield was 32%.