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Synthesis of carbon‐14 labelled cis ‐malonato [(4 R ,5 R )‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane] platinum(II) (ski 2053R)
Author(s) -
Kim DaeKee,
Kim Youngseok,
Rim Jonggill,
Kim Ganghyeok,
Gam Jongsik,
Song Sungkun,
Yoo Kwanghee,
Kim Key H.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340208
Subject(s) - chemistry , dioxolane , isopropyl , platinum , tartaric acid , yield (engineering) , medicinal chemistry , stereochemistry , radiochemistry , organic chemistry , catalysis , materials science , metallurgy , citric acid
The synthesis of 14 C‐labelled cis ‐malonato[(4 R ,5 R )‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐ 14 C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5%.