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A practical approach to the synthesis of 14 C‐labeled amino acid and simple peptide
Author(s) -
Ekhato I. Victor,
Huang Che C.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340202
Subject(s) - chemistry , carboxylation , glycine , hydrochloride , peptide , amino acid , peptide synthesis , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , catalysis
A convenient method for the synthesis of phenylmethyl N‐methyl ( carboxy ‐ 14 C) glycine hydrochloride (Z) is described. It involves the carboxylation of transmetalated organostannane compound 4 which itself is accessible by established procedure. Success in preparing the labelled amino acid Z enabled us to synthesize target N‐glycyl‐N‐methyl( carboxy ‐ 14 C) glycine ( 10 ) by conventional coupling protocol.