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Synthesis of 3‐[ 18 F]‐fluoromethyl‐TCP 1 , A potential tool for pet study of the nmda receptor channel complex
Author(s) -
Ponchant M.,
Kamenkaj M.,
Crouzel C.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311115
Subject(s) - chemistry , nmda receptor , receptor , radiochemistry , stereochemistry , biochemistry
In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3‐fluoromethyl‐TCP 3 , 3‐[ 18 F]‐fluoro‐methyl‐TCP 4 was synthesized by a nucleophilic substitution of 3‐bromomethyl‐TCP 5 with [ 18 F − ].