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Deuteriation of RS 87476
Author(s) -
Souchet Michel,
Pascal Jean Claude
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311006
Subject(s) - chemistry , piperazine , deuterium , stereochemistry , medicinal chemistry , organic chemistry , quantum mechanics , physics
Deuteriation of toluidine in 2 H 2 O and synthesis of N‐[(d 5 ‐phenyl phenyl)methyl] piperazine are described. These intermediates permit the incorporation of 7 deuterium atoms into RS 87476. This efficient synthesis of polydeuterated RS 87476 facilitated its use in preliminary animal studies and as an internal standard in RS 87476 quantification.