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Synthesis and binding to striatal membranes of no carrier added I‐123 labeled 4′‐iodococaine.
Author(s) -
Metwally S. A. M.,
Gatley S. J.,
Wolf A. P.,
Yu D.W.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310307
Subject(s) - chemistry , tributyltin , reuptake , membrane , dopamine , pharmacology , binding site , biophysics , neuroscience , biochemistry , serotonin , receptor , organic chemistry , psychology , medicine , biology
An 123 I labeled cocaine analog, 4′‐[ 123 I]iodococaine, has been prepared by oxidative destannylation of the tributyltin analog and shown to interact with cocaine binding sites in rat brain striatal membranes. It may thus be a suitable SPECT radiotracer for studies of the dopamine reuptake site in neurodegenerative diseases.