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Synthesis of tritiated threonine with a high specific activity
Author(s) -
Delacotte JeanMichel,
Galons Hervé,
Schott Dominique,
Morgat JeanLouis
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580291006
Subject(s) - chemistry , tritium , threonine , specific activity , tritium illumination , tritiated water , radiochemistry , stereochemistry , biochemistry , serine , phosphorylation , enzyme , physics , nuclear physics
The synthesis of the trichloromethyl analogue of benzyloxycarbonyl‐threonine is described. This precursor was reduced by tritium gas to give [methyl‐ 3 H 3 ]‐threonine and its allo isomer. They were separated by HPLC using a chiral stationnary phase. They have a molar specific activity of 3190 GBq/mmol, 86 Ci/mmol.