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An improved synthetic procedure for the preparation of 195m Pt labelled anti‐tumour complexes
Author(s) -
Jackson H.,
McAuliffe C. A.,
Perera A.,
Sharma H. L.,
Tinker N. J.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580291004
Subject(s) - carboplatin , chemistry , cisplatin , yield (engineering) , radiochemistry , combinatorial chemistry , nuclear chemistry , chemotherapy , surgery , medicine , materials science , metallurgy
An improved synthetic procedure for the preparation of high specific activity 195m Pt labelled cisplatin, carboplatin and iproplatin is reported. The procedure involves synthetic strategies which optimise the yields at each stage of the synthesis, giving products of high purity and in high yield (ie. cisplatin and carboplatin, 43%, and iproplatin, 22%). A new procedure for the synthesis of carboplatin using silver 1,1‐cyclobutanedicarboxylate is also reported.