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A general approach to the synthesis of 14 C‐labeled photoactive acrylic acids
Author(s) -
Mohammad Taj,
Morrison Harry
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290906
Subject(s) - chemistry , knoevenagel condensation , malonic acid , acrylic acid , condensation reaction , condensation , organic chemistry , reaction conditions , catalysis , physics , monomer , thermodynamics , polymer
Condensation of aromatic carboxaldehydes with [2‐ 14 C]‐ malonic acid under Knoevenagel conditions provides corresponding β‐aryl substituted [α‐ 14 C]‐acrylic acids. The reaction is applicable to both aromatic and heteroaromatic aldehydes under controlled reaction conditions leading to moderate to good yields.