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A concise synthesis of [ carbonyl ‐ 11 C]melatonin and N ‐[carbonyl‐ 11 C]acetylserotonin
Author(s) -
Tada Masao,
Oikawa Atsushi,
Iwata Ren,
Sato Kazunori,
Sugiyama Hiroshi,
Takahashi Hiromu,
Wakui Akira,
Fukuda Hiroshi,
Kubota Kazuo,
Abe Yoshinao,
Yamaguchi Tatsuo,
Fujiwara Takehiko,
Sato Tachio,
Ido Tatsuo
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290812
Subject(s) - chemistry , yield (engineering) , acetic acid , carbon dioxide , carbon 14 , melatonin , specific activity , radiochemistry , medicinal chemistry , nuclear chemistry , organic chemistry , enzyme , medicine , materials science , physics , quantum mechanics , metallurgy
Abstract Rapid chemical syntheses of [carbonyl ‐ 11 C]melatonin and N ‐[ carbonyl ‐ 11 C]acetylserotonin starting from [ 11 C]carbon dioxide are described. The radiochemical yield (based on [ carbonyl ‐ 11 C]‐acetic acid), purity, and the specific activity (end of bombardment) of the former are 12%, >98%, and 4.2 Ci/μmol, respectively. The latter is also synthesized with the same radiochemical yield, purity, and specific activity. The total times required for their syntheses are ca. 45 min, respectively.