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Synthesis of [20,21‐ 13 C 2 ]‐progesterone
Author(s) -
Caballero Gerardo M.,
Gros Eduardo G.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290711
Subject(s) - chemistry , nitrile , iodide , derivative (finance) , grignard reaction , condensation , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , physics , reagent , financial economics , economics , thermodynamics
The synthesis of, [20,21‐ 13 C 2 ]‐progesterone ( 9 ) from androst‐4‐ene‐3,17‐dione ( 1 ) is described. Labels were introduced by two procedures, namely, condensation of 1 with K 13 CN and Grignard reaction of nitrile derivative 7 with [ 13 C]‐methylmagnesium iodide. Location of labels was confirmed by 13 C‐NMR spectroscopy.