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An improved synthesis of [ 15 N] labelled acetamide and acetonitrile
Author(s) -
Morgan D. R.,
Dorn H. C.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290707
Subject(s) - chemistry , acetamide , acetonitrile , organic chemistry , combinatorial chemistry , chromatography
An improved synthesis of [ 15 N] labelled acetamide and acetonitrile is described which provides these compounds in yields of 85% and 64%, respectively. The key difference in the present preparation is the use of 2,2,2‐trifluoroethyl acetate for the reaction with 15 NH 4 OH.